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乳腺癌微环境组成与高PD-L1表达相关

Vasyl Chekhun¹, Yelyzaveta Lukianova¹, Oleksandr Mushii²

¹RE Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, the NAS of Ukraine, Vasylkivska Street, 45, 03022, Kyiv, Ukraine.

|January 13, 2026

概括

乳腺癌 (BC) 中高PD-L1表达与免疫抑制瘤微环境 (TME) 相相关. 这包括更多的亲瘤原生免疫细胞,像IL-10这样的改变细胞因子,以及重塑的细胞外基质,影响BC进展.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

乳腺癌 (BC) 的异质性使诊断,治疗和预后复杂化.
瘤微环境 (TME) 显著影响BC发育和进展.
了解TME特征对于BC管理至关重要.

研究的目的:

在基于PD-L1表达的早期BC中描述TME.
分析免疫细胞透 (CD68 +,CD163 +,巨细胞),细胞因子概况 (IL-6,IL-10,TNF-α) 和细胞外矩阵组件 (VIM,TGF-β1,COL1A1,COL3A1,MMPs,LOX,PLOD).
为了确定与免疫抑制和促进瘤的表型相关的TME特征.

主要方法:

来自124名患有I-II期BC的患者的术后材料的分析.
对TME标记物的免疫性化分析.
实时RT-PCR用于mRNA基因表达.
针对血清细胞因子水平的ELISA.

主要成果:

高PD-L1表达与CD163+巨细胞 (2.9倍) 和巨细胞 (2.5倍) 的增加有关.
在高PD-L1BC中,血清IL-10升高和IL-6降低.
在高PD-L1瘤中增加了TGF-β1 (2.13x),COL1A1 (13.24%),MMPs (-1, -8, -13, -2, -9) 和LOX (2.48x).

结论:

在BC中的高PD-L1表达与免疫抑制性TME有关.
这包括增加了亲瘤原生的免疫细胞的透.
细胞因子概况的变化和 stromal 矩阵的重塑与BC中的高 PD-L1 表达有关.

关键词:

乳腺癌是什么? 乳腺癌是什么乳腺瘤异质性乳腺瘤异质性在PD-L1中.瘤微环境是一个微环境.

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