弥合模拟差距:在使用计算机辅助检测软件进行结核查时,印刷X射线片和数字图像的比较
Andrew J Codlin1,2, Thang P Dao3, Binh H Nguyen3
1Friends for International TB Relief, Ha Noi, Viet Nam. andrew.james.codlin@ki.se.
BMC global and public health
|January 14, 2026
概括
根基软件在解释DICOM和JPEG文件中的胸部X射线 (CXR) 图像方面表现相似,性能优于人类读取器. 这支持其在资源有限的环境中用于结核病查的应用.
科学领域:
- 医学成像分析 医学成像分析
- 医疗保健中的人工智能
- 放射学 信息学 信息学
背景情况:
- 计算机辅助检测 (CAD) 软件帮助放射科医生进行胸部X射线 (CXR) 解释,解决放射科医生的短缺和变化.
- 大多数CAD软件需要数字成像和医学通信 (DICOM) 文件,限制在印刷X射线膜的设置中使用.
- 世界卫生组织推的Genki软件独特地处理DICOM和联合摄影专家组 (JPEG) 文件,但其JPEG性能需要评估.
研究的目的:
- 独立评估Genki CAD软件在解释JPEG文件中的CXR图像时的性能,与DICOM文件相比.
- 评估Genki软件满足结核病 (TB) 查目标产品配置文件 (TPP) 标准的能力.
主要方法:
- 使用了来自越南结核病查的1466个成年CXR图像的测试库.
- 根基软件处理了每个CXR图像的DICOM和JPEG版本.
- 使用中位数异常得分,接收器运行特征曲线 (AUC) 下的面积和灵敏度/特异性来评估性能.
主要成果:
- 对于DICOM (0.94) 和JPEG (0.92) 文件,Genki软件显示了可比的曲线下面面积 (AUC) 值.
- 当对人类级别的灵敏度进行校准时,Genki在DICOM (95.2%) 和JPEG (92.1%) 文件中实现了显著更高的特异性.
- 在对90%的灵敏度进行校准时,Genki满足了TPP高灵敏度,高特异性选的标准,具有DICOM (89.3%) 和JPEG (81.1%) 的特异性.
结论:
- 对于DICOM和JPEG CXR文件解释,Genki软件的性能相当于人类阅读器的性能.
- 它处理JPEG文件的能力提高了在资源有限的设置中缺乏TB查数字基础设施的可用性.
- 进一步的研究应该集中在现实世界的实施和表现在不同的人群和临床环境.
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