成年鼻腔微生物组的组成和动态
Cindy M Liu1, Lise Tornvig Erikstrup2, Sofie M Edslev3
1Antibiotic Resistance Action Center, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA. cindyliu@gwu.edu.
Microbiome
|January 14, 2026
概括
鼻子微生物组有九个不同的社区状态 (CST),它们在稳定性和病原体存在方面有所不同. 调节这些鼻腔微生物组动态可能提供减少病原体殖民和改善健康的策略.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 免疫学 免疫学 免疫学
背景情况:
- 鼻子微生物群,包括开始性和病原体,在维持人类健康方面发挥着至关重要的作用.
- 了解鼻腔微生物动态对于制定有针对性的健康干预措施至关重要.
研究的目的:
- 在一大群成年人中描述鼻腔社区状态类型 (CST).
- 研究鼻腔微生物群落的稳定性,过渡模式和影响因素.
- 为了确定潜在的微生物相互作用和影响病原体殖民的宿主因素.
主要方法:
- 对1608名成年人进行横截面分析,并对149名8至22个月的个人进行纵向抽样.
- 根据细菌密度和指标分类,确定了九种鼻腔社区状态类型 (CST).
- 分析核心种群稳定性,病原体居住时间和物种间相互作用.
主要成果:
- 确定了九种不同的鼻腔社区状态类型 (CST),稳定性和过渡动态各不相同.
- 像Staphylococcus epidermidis这样的核心共生菌是稳定的,而像Staphylococcus aureus这样的病原体的居住时间较短.
- Dolosigranulum pigrum和Corynebacterium物种之间的相互作用与 Staphylococcus aureus殖民减少相关. 男人表现出更高的细菌密度和病原体殖民,而女性则具有更稳定的开始性CST. 随着年龄的增长,S. aureus的数量减少,Enterobacterales的数量增加.
结论:
- 鼻子微生物组的动态受到年龄和性别等宿主因素的影响,为健康调节提供了机会.
- 针对鼻子微生物组的组成和稳定性可能是减少病原体殖民的策略.
- 对微生物组调制的进一步研究可能会导致改善鼻腔健康和疾病预防的策略.
相关概念视频
Nose and Nasal Cavity
10.4K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
10.4K
Anatomy of Respiratory System I: Upper Respiratory Tract
4.7K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
4.7K
Anatomy of the Intestines
86.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.7K
Olfactory Receptors: Location and Structure
11.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.2K
Defense Mechanism Against Infection
9.1K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.1K
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K


