在接受前列腺放射治疗的患者中,泌尿生殖系统的毒性,功能和生活质量-一个范围审查
Casper Vrij1,2, John Heesakkers1, Evert Jan Van Limbergen3,4
1Department of Urology, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.
Lower urinary tract symptoms
|January 14, 2026
概括
前列腺放射治疗,包括外部束辐射疗法 (EBRT) 和支臂疗法 (BRT),经常导致尿路不良事件 (UAE). 长期的泌尿功能可能会恶化或显示最小的改善,需要进一步的研究以获得更好的患者结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 辐射瘤学 辐射瘤学
- 在瘤学瘤学.
背景情况:
- 前列腺放射治疗 (外部束辐射疗法[EBRT]和支臂疗法[BRT]) 是前列腺癌的常见治疗方法.
- 尿路不良事件 (UAE) 和对下尿路功能和生活质量的影响是接受治疗的患者的重大担忧.
研究的目的:
- 进行范围审查,检查前列腺放射治疗 (EBRT和BRT) 对UAE,下泌尿道功能和生活质量的影响.
- 从现有文献中综合发现,以告知患者管理和选择.
主要方法:
- 使用PubMed,Cochrane和Embase (OVID) 进行了全面的文献搜索.
- 包括23项相关研究,并讨论了这些研究的结果.
主要成果:
- 前列腺放射治疗后UAEs很常见,大约三分之一经历急性事件,四分之一经历晚期事件 (等级≥2).
- 长期的泌尿功能显示轻度基线症状的患者的改善或恶化最小,而中度到重度的症状可能会改善,但仍然令人烦.
- 泌尿动力学数据表明,峰值流量率的短期下降和空气后残留量的增加,通常在长期内恢复到基线.
结论:
- 前列腺放射治疗显著影响尿路功能和生活质量,常见的急性和晚期不良事件.
- 目前的证据表明,需要改进患者管理和选择策略,以减轻生殖尿道毒性.
- 进一步的研究是必要的,以提高患者的结果和生活质量与当代放射治疗技术.
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