在器官移植中进行Candida auris查
Edison J Cano Cevallos1, Aaron D Mishkin2
1Division of Infectious Diseases, Memorial Healthcare System, Hollywood, Florida, USA.
概括
多种药物耐药的Candida auris对移植受体构成重大威胁. 缺乏标准化查,需要紧急,以移植为重点的研究,以获得更好的患者结果.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
- 临床微生物学 临床微生物学
背景情况:
- 黄是一种多药性耐药酵母,由于免疫抑制和侵入性手术,对移植受体具有高风险影响.
- 尽管已知殖民化和持续性,但对移植捐赠者和接受者的标准化查尚未明确.
研究的目的:
- 在移植群体中审查和综合Candida auris查的当前方法.
- 确定知识上的差距,并指导未来的研究,以减轻移植前的风险.
主要方法:
- 审查已发表的疫情报告,监测研究,实验室指导和公共卫生建议.
- 综合了基于风险的查标准,诊断方式以及ICU数据对移植机构的适用性数据.
主要成果:
- 查策略通常是基于入院或疫情驱动的. 分子测定与较慢的基于培养的方法相比,提供了快速检测.
- 有限的移植特异性证据表明,侵袭性病例中经常存在殖民和高死亡率. 没有经过验证的非殖民化协议存在.
结论:
- 有必要进行前性,以移植为重点的研究,以建立最佳的术后查方案.
- 进一步的研究应该量化殖民到感染的进展风险,并评估查干预措施的临床影响.
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