在具有不同HBV血清模式的个体中使用双重ART
Thomas Swaine1, Sanjay Bhagani1,2
1Department of HIV Medicine, Royal Free London NHS Trust.
Current opinion in HIV and AIDS
|January 14, 2026
概括
治疗艾滋病毒的两种药物方案 (2DR) 减少了药物负担,但需要仔细查乙型肝炎 (HBV). 切换到2DRs具有较低的HBV再激活风险,特别是含有拉米武丁的选择.
科学领域:
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
- 抗逆转录病毒疗法是一种治疗方法.
背景情况:
- 两种药物方案 (2DR) 越来越多地被推用于艾滋病毒治疗,以尽量减少药物负担和毒性.
- 在2DR中排除了诺福维尔和拉米武丁/emtricitabine,这引发了人们对乙型肝炎病毒 (HBV) 获取和重新激活的担忧.
研究的目的:
- 审查2DRs对艾滋病毒感染者的HBV获取和重新激活的影响.
- 评估与不同2DR配方相关的HBV再激活风险.
主要方法:
- 对病例系列,队列研究和随机对照试验的系统审查,评估2DRs患者的HBV结局.
- 基于特定药物组合和先前的HBV暴露 (HBsAg阳性) 的HBV再激活 (HBVr) 风险的分析.
主要成果:
- 在切换到含有拉米武丁的2DR时,HBVr的风险是可以忽略不计的.
- 转换为诺福维尔和拉米武丁/埃姆特里西塔宾无治疗的患者的整体HBVr风险较低 (~1%).
- 即使是远程的HBsAg阳性也显著增加了HBVr.的风险.
结论:
- 切换前的HBV血清学评估对于HIV感染者启动2DRs至关重要.
- 对于没有先前暴露或没有HBsAb的个人,建议接种HBV疫苗.
- 建议进行仔细的监测和患者咨询,特别是关于含有拉米武丁的2DRs的低HBVr风险.
相关概念视频
01:10Blood Typing
2.3K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
2.3K
02:45Blood Transfusion and Agglutination
14.0K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.0K
01:19Rh Blood Group
2.7K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.7K
02:20Blood Types
22.3K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
22.3K
01:12The ABO Blood Group
4.6K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
4.6K