孕期高血压和孕前中母亲肥胖和代谢功能障碍之间的相互作用:一个前性的出生队列研究
Jiayi Chen1,2, Yibing Zhu2, Junwei Liu1,2
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Journal of clinical hypertension (Greenwich, Conn.)
|January 14, 2026
概括
代谢不健康或超重/肥胖的孕妇面临更高的妊娠高血压和子宫前的风险. 代谢异常和超重相互作用,显著增加这些妊娠并发症.
科学领域:
- 产科和妇科 产科和妇科
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 妊娠高血压 (GH) 和妊娠前 (PE) 是重要的妊娠并发症.
- 代谢性肥胖现象型越来越多地被认为是不利的孕产妇结果的风险因素.
- 了解代谢状态和体重之间的相互作用对于风险预测至关重要.
研究的目的:
- 调查代谢性肥胖现象与妊娠高血压 (GH) 和孕前 (PE) 的风险之间的关联.
- 探索肥胖和与GH和PE有关的代谢异常之间的潜在相互作用.
- 根据怀孕前的BMI和代谢状态对参与者进行分类.
主要方法:
- 在中国进行的前性分娩队列研究,涉及21,893名单身孕妇.
- 根据怀孕前的BMI和代谢状态将参与者分为肥胖代谢表型.
- 基于已确定的标准诊断GH和PE,包括血压和末端器官功能障碍.
主要成果:
- 代谢不健康的正常体重,代谢健康的超重/肥胖以及代谢不健康的超重/肥胖表型与GH和PE的风险显著增加有关.
- 代谢健康的体重不足女性显示,GH的风险降低.
- 超重和代谢不健康之间的附加相互作用显著增加了GH风险.
结论:
- 代谢异常和超重/肥胖都独立地增加了GH和PE的风险.
- 超重和代谢不健康之间的显著相互作用效应放大了这些妊娠并发症的风险.
- 识别特定的代谢性肥胖表型对于管理和预防GH和PE至关重要.
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