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Updated: Jan 15, 2026

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对PARP抑制剂Niraparib的生理学基础的药动力学建模

Gareth J Lewis1, Roxanne C Jewell2, Anu Shilpa Krishnatry3

  • 1GlaxoSmithKline, DMPK, Preclinical Sciences, Stevenage, UK.

CPT: pharmacometrics & systems pharmacology
|January 14, 2026
PubMed
概括

一个新的基于生理学的尼拉帕里布的药理动力学模型表明,它被碳氧乙酶1代谢. 该模型预测了在各种虚拟人群中对niraparib的药物相互作用风险最小.

关键词:
这是一种PARP抑制剂.在Simcyp,你会发现.癌症 癌症 癌症 癌症 癌症药物药物相互作用 (DDI)建模建模是什么意思尼拉帕里布里布里布.基于生理学的药理动力学 (PBPK)

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