加拿大各地执法机构扣押的含芬太尼的药物样本的趋势
Shaleesa Ledlie1,2, Ria Garg1,2,3, Pamela Leece4,5,6
1Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
Addiction (Abingdon, England)
|January 14, 2026
概括
加拿大加拿大加拿大加拿大加拿大加拿大
科学领域:
- 法医科学 法医科学 法医科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 加拿大面临着由芬太尼驱动的严重毒药危机.
- 不受监管的药物供应越来越多地含有芬太尼与其他物质混合,如二,兴奋剂和西拉.
- 与阿片类药物相关的危害的区域差异表明加拿大药物供应组成的差异.
研究的目的:
- 在全国范围内分析含芬太尼的毒品扣押趋势.
- 将这些趋势与加拿大各省和地区进行比较.
- 了解非法毒品供应的不断变化的组成.
主要方法:
- 从2020年2月到2024年12月进行了重复的横截面分析.
- 执法部门扣押的含芬太尼的药物样本由加拿大卫生部的药物分析服务部门进行分析.
- 随着时间的推移和按地区分析了扣押数量,率和检测到的药物类别/物质的趋势.
主要成果:
- 在2020年至2024年期间,在全国范围内,每季度含芬太尼的药物被查获的数量增加了24.4%.
- 英国哥伦比亚省和阿尔伯塔省在2024年报告了最高的年度发作率.
- 检测到的法和甲基芬太尼的显著增加,同时在发作中发现了二和西拉的比例上升.
结论:
- 从2020年到2024年,含芬太尼的药物获在加拿大增加了24%.
- 这些发作越来越多地涉及多种物质,包括二类药物,西拉和强效芬太尼类似物.
- 这凸显出一个复杂而不断变化的非法毒品供应构成重大公共卫生风险.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
908
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
908
Drug Concentrations: Measurements
1.1K
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
1.1K
Prescription, Nonprescription and Orphan Drugs
1.2K
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
1.2K
Drug Control Governance: Regulatory Bodies and Their Impact
489
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
489
Drug Regulation
2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K
Opioid Analgesics: Morphine and Other Natural Cogeners
848
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
848


