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维生素D状况与晚期新生儿败血症的死亡率和微生物谱的关联:一项比较观察性研究

Anju Yadav¹, Pratima Anand², Rani Gera³

¹Paediatrics, Employees' State Insurance Corporation (ESIC) Medical College and Hospital, Faridabad, IND.

|January 14, 2026

概括

新生儿和母亲的维生素D缺乏会增加晚发性新生儿败血症 (LONS) 的风险. 在LONS病例中,较低的维生素D水平与较高的死亡率和特定的阴性菌和真菌感染相关.

科学领域:

新生儿科学新生儿科学
营养免疫学营养免疫学
传染性疾病传染性疾病

背景情况:

晚期新生儿败血症 (LONS) 是婴儿疾病和死亡的主要原因,特别是在发展中国家.
维生素D缺乏是一个日益严重的全球健康问题,对免疫功能有潜在的影响.

研究的目的:

调查LONS.新生儿中维生素D缺乏症的流行情况.
检查母亲的维生素D状况与婴儿的LONS之间的关联.
探索维生素D水平,微生物特征和LONS.中的死亡率之间的关系.

主要方法:

一项观察性研究将160名新生儿与LONS进行了比较,与160名匹配的非杀菌对照进行了比较.
收集的数据包括新生儿和母亲的25OH) 维生素D水平,微生物培养和临床结果.
统计分析比较了群体之间的维生素D状况,感染类型和死亡率.

主要成果:

与对照组相比,败血症新生儿及其母亲的维生素D含量明显较低.
维生素D缺乏在LONS组 (40.6%) 与对照组 (20.6%) 中更为普遍.
严重的维生素D缺乏与グラム阴性 (Acinetobacter,大肠杆菌,Klebsiella) 和真菌 (Candida) 败血症有关. 在维生素D水平较低的新生儿中,死亡率更高.

结论:

新生儿和母亲的维生素D缺乏是LONS的重要危险因素.
维生素D状态与特定的病原体和LONS中死亡率的增加有关.
维持足够的维生素D水平可能对预防LONS和改善结果至关重要.

关键词:

培养证明的新生儿败血症晚期发作的新生儿败血症死亡率死亡率生物体简介生物体简介维生素D水平维生素D水平

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