%dd-cfDNA:心脏/肺移植监测的新前沿?
Sean Agbor-Enoh1,2,3,4, Ethan Fraser2,4, Nitin Nadella2,5
1Genomic Research Alliance for Transplantation (GRAfT), Bethesda, MD, United States.
概括
测量捐赠者衍生的无细胞DNA (%dd-cfDNA) 的百分比的非侵入性血液检测显示出检测胸部移植排斥的前景. 本综述综合了证据,讨论了局限性,并探索了未来的cfDNA方法来进行个性化监测.
科学领域:
- 移植免疫学 移植免疫学
- 发现生物标志物的发现.
- 非侵入性诊断是一种非侵入性诊断.
背景情况:
- 整体移植的拒绝威胁到长期的移植成功.
- 目前的监测方法,如活检,是侵入性的,并有局限性.
- %dd-cfDNA是一个有前途的非侵入性生物标志物,用于全移植损伤.
研究的目的:
- 对胸部移植中%dd-cfDNA的证据进行审查.
- 为了划出当前%dd-cfDNA测试的局限性.
- 探索新兴的cfDNA技术,以改善监测.
主要方法:
- 对胸部移植接受者的%dd-cfDNA研究的系统文献综述.
- 从中央商业%dd-cfDNA测试中分析性能数据.
- 讨论已发表的研究中报告的局限性和混因素.
主要成果:
- 已发表的研究报告了%dd-cfDNA测试的异质性能.
- 显著的盲点和混因素影响了当前的 %dd-cfDNA 测试.
- 新兴的cfDNA方法为更个性化的监测提供了潜力.
结论:
- %dd-cfDNA显示了作为胸部全移植损伤的非侵入性生物标志物的潜力.
- 目前的测定有局限性,需要仔细解释.
- 未来的cfDNA策略可能会减少对移植监测的侵入性活检的依赖.
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