在一般人群中脂肪肝指数和手腕-脚脉动波速之间的关联 - 一项横截面研究
Daisuke Tokutake1, Yuichi Akasaki1, Shuya Shinchi1
1Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan.
Circulation reports
|January 14, 2026
概括
脂肪肝指数 (FLI) 与日本成年人的动脉硬有关. 较高的FLI分数与增加的脚脉冲波速率 (baPWV) 相相关,这是心血管风险的标志物.
科学领域:
- 心血管健康 心血管健康
- 代谢功能障碍 代谢功能障碍
- 公共卫生 公共卫生
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 诊断通常依赖于超声波.
- 脂肪肝指数 (FLI) 为MAFLD提供了一个更简单的诊断替代方案.
- 腕脉冲波速度 (baPWV) 是动脉硬和心血管事件预测的一个关键指标.
研究的目的:
- 为了研究脂肪肝指数 (FLI) 和臂脚脉冲波速度 (baPWV) 之间的关联.
- 评估FLI是否可以作为一般日本人口动脉硬的预测指标.
主要方法:
- 一项横截面研究包括10,122名日本成年人 (年龄≥18岁).
- 排除标准包括心房动,下肢动脉疾病,严重的大动脉狭窄或缺失的数据.
- 多变量逻辑回归分析了FLI (分类和连续) 与升高的baPWV (≥1,800 cm/s) 之间的关联.
主要成果:
- 中等风险 (FLI ≥30和<60) 和高风险 (FLI ≥60) 组的参与者与低风险组 (FLI <30) 相比,baPWV升高的几率明显更高.
- 中度和高风险组的几率比 (OR) 分别为1.47 (95% CI 1.20-1.79) 和1.78 (95% CI 1.33-2.38).
- 每增加10个单位的FLI与增加1.16倍的升高baPWV的几率 (95% CI 1.10-1.22).
结论:
- 脂肪肝指数 (FLI) 与动脉硬度有显著的相关性.
- 在日本一般人群中,FLI显示出作为评估心血管风险的标志物的潜力.
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