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在美国,量化移植非最佳,已故捐赠者脏的中心级侵略性
Teresa Po-Yu Chiang1, Mackenzie A Eagleson2,3, Jennifer D Motter1
1Department of Surgery, NYU Grossman School of Medicine, New York City, NY.
Transplantation direct
|January 14, 2026
概括
移植中心在接受低于最佳脏 (SOK) 报价方面显示出显著的差异. 提供对比数据的中心可能会鼓励更多地接受SOK脏,改善对已故捐赠脏移植的获取.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 公共卫生 公共卫生
背景情况:
- 低最佳脏 (SOK) 供应对于最大限度地利用已故捐赠脏移植 (DDKT) 来说至关重要.
- 了解中央层面的决策是改善所有可移植脏使用的关键.
研究的目的:
- 量化接受SOK已故捐赠者移植报价的中心水平变化.
- 分析不同SOK亚型中DDKT利用的不平等情况.
主要方法:
- 利用2021-2023年的国家注册表数据来提供DDKT.
- 分析的SOK亚型包括供体年龄,感冒缺血时间,C型肝炎状态,肌水平,DCD,KDPI和PHS增加了风险.
- 用于利用不平等的吉尼系数和用于中心变化的多层逻辑回归 (mOR).
主要成果:
- 72.6%的DDKT涉及至少有一个SOK特征的捐赠者.
- 在SOK DDKT利用方面观察到显著的不平等 (Gini=0.53).
- 中心接受的SOK报价中位数为7.2%,非SOK报价为12.5%,SOK报价被更多的中心拒绝 (中位数为9比5).
结论:
- 移植中心在接受特定SOK报价方面表现出相当大的差异.
- 为中心提供SOK接受模式的同行比较数据可能会鼓励增加利用率.
- 这最终可以通过使用更适合临床的SOK来改善患者获得DDKT的机会.
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