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Updated: Jan 15, 2026

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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开发UM-203,一个可逆的共价性STING对手

Leonard Barasa1,2, Leo DeOrsey1,2, Maeve D O'Reilly1,2

  • 1Program in Chemical Biology, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, United States.

ACS medicinal chemistry letters
|January 14, 2026
PubMed
概括

研究人员开发了UM-203,一种新的可逆共价抑制剂,向干扰素基因 (STING) 途径的循环GMP-AMP合成酶 (cGAS) 刺激器. 这种化合物有效地抑制了人类和小鼠系统中的STING信号传递,为自身免疫性疾病治疗提供了潜力.

关键词:
细胞因子 (cytokines) 是一种细胞因子.寡合化是指一种氧化物.干扰素基因的刺激剂.在TBK1中,这是一种I型干扰子.抑制剂抑制剂的使用

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