青少年慢性二胺滥用的多系统后续:一个强调全面历史记录的重要性的案例
Justin M Howe1, Jay Vora2, Abhishek Reddy3
1Howe, BS, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
Psychopharmacology bulletin
|January 14, 2026
概括
青少年滥用迪芬胺,通常用于情绪调节,可能导致严重的神经和精神问题. 早期识别和创伤信息化的护理对于管理这些风险和预防伤害至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 青少年医学 青少年医学
- 精神病学是一个精神病学.
背景情况:
- 脱胺 (DPH) 是一种OTC抗组胺,由于其精神活性作用,青少年越来越多地滥用它.
- 慢性DPH滥用存在重大风险,包括神经,精神和胃肠道并发症,特别是在脆弱的年轻人中.
- DPH的可访问性和感知安全性有助于青少年滥用它.
研究的目的:
- 突出与青少年二胺滥用相关的诊断挑战.
- 为了强调慢性DPH使用模仿或恶化精神和神经疾病的潜力.
- 强调早期识别和创伤知情管理在预防伤害方面的重要性.
主要方法:
- 案例介绍:一个有TBI,MDD和饮食障碍史的十几岁女性因DPH过量服用而入院.
- 追溯分析了两年的未披露的每日DPH滥用的历史.
- 多系统症状与慢性DPH使用和TBI/发作的相关性.
主要成果:
- 患者表现出多系统症状,包括发作,饮食失调和与慢性DPH滥用相关的行为变化.
- DPH滥用复杂的诊断,可能掩盖潜在的疾病,并促进多药学.
- 停止DPH和结构化精神病治疗导致患者的改善.
结论:
- 在出现重叠的精神,神经和胃肠道症状的青少年中,应考虑滥用二胺.
- 定期的心理社会查和对非传统药物滥用的认识对于及时诊断至关重要.
- 创伤知情管理和早期干预对于解决青少年DPH滥用问题至关重要.
相关概念视频
Substance Use Disorders Affecting Sleep
398
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
398
Sedatives and Hypnotics Drugs: Miscellaneous Agents
508
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
508
Drug Abuse and Addiction: Pharmacological Phenomena
1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K
Attention-Deficit/Hyperactivity Disorder
743
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
743
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
350
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
350
Pharmacovigilance
1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K


