全球模式,时间趋势以及1990年至2021年伯基特淋巴瘤的潜在非传染性风险因素
Shi-Kai Jin1, Jun-Ting Lyu2, Zi-Yu Feng1
1Department of Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Blood and lymphatic cancer : targets and therapy
|January 14, 2026
概括
自1990年以来,伯基特淋巴瘤 (BL) 发病率增加了三倍,男性和年轻人患病率更高. 低骨密度和童年性虐待等危险因素显示出多种关联,而烟草使用似乎是保护性的.
科学领域:
- 血液学 血液学 血液学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 伯基特淋巴瘤 (BL) 的全球健康负担和非传染性风险因素在人口统计和地理位置上表现出显著的异质性.
- 了解这些变异对于有针对性的公共卫生干预和临床管理至关重要.
研究的目的:
- 根据2021年全球疾病负担研究,使用发病率,死亡率,流行率和残疾调整寿命年 (DALYs) 来估计BL的健康负担.
- 分析趋势并预测BL的未来健康负担.
- 确定和评估非传染性风险因素对BL的影响.
主要方法:
- 用于BL健康指标的2021年全球疾病负担数据.
- 雇员Joinpoint回归分析健康负担趋势的年度百分比变化 (AAPC).
- 应用贝叶斯年龄-时期-队列模型用于未来的预测.
- 使用汇总暴露值 (SEV) 分析非传染性风险因素.
主要成果:
- 全球BL发病率在2021年达到19,073,是1990年以来的三倍增长,男性的负担更高,特别是20岁以下的男性.
- 在佛得角观察到显著的增长趋势,而格鲁吉亚则显示下降 (1990-2021年).
- 预计到2040年,全球发病率和死亡率将分别下降14.7%和24.7%,但预计20-54岁年龄组的负担将增加.
- 鉴定了低骨矿物质密度作为老年男性的风险,女性的童年性虐待,以及烟草使用的反向关联.
结论:
- 伯基特淋巴瘤表现出不同的年龄,性别和区域分布模式.
- 对异质风险因素的进一步研究对于制定有效的BL健康政策和临床实践至关重要.
更多相关视频
09:43An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
9.6K
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
19.2K
相关概念视频
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Pulmonary Tuberculosis I
822
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
822
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Non-LTR Retrotransposons
13.2K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.2K
Pulmonary Tuberculosis II
1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
Mechanisms of Retrovirus-induced Cancers
6.8K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.8K
