在双语非阿尔茨海默氏症八十岁的双语非阿尔茨海默氏症患者中,原发性渐进性失言症的Logopenic变体
Ícaro Araújo de Sousa1, Bruno Henrique Carneiro Costa2, Isabel Junqueira de Almeida2
1Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.
Dementia & neuropsychologia
|January 14, 2026
概括
这项案例研究突出了罕见的logoopenic变体初级渐进性失言症 (lvPPA) 呈现,具有双语语言效应和负的阿尔茨海默病生物标志物. 这表明非阿尔茨海默氏症的病理可能会模仿lvPPA.
科学领域:
- 神经学 神经学
- 语言学的语言学.
- 老年病的医生 老年病的医生
背景情况:
- 逻辑变异性原发性渐进性失言症 (lvPPA) 通常会出现词查找困难.
- 双语可以影响神经退行性语言障碍的表现和进展.
- 将lvPPA与其他痴呆症区分开来,对于准确的诊断和管理至关重要.
研究的目的:
- 描述一种具有双语不对称性和非典型生物标志物特征的lvPPA独特病例.
- 为了探索 lvPPA 类症状的潜在替代病因.
- 强调液体生物标志物在差异诊断中的作用.
主要方法:
- 临床病例介绍和详细的神经学检查.
- 神经成像 (结构和功能) 评估大脑缩和新陈代谢.
- 对阿尔茨海默病等离子体生物标志物的分析 (Aβ42/40,p-tau217).
主要成果:
- 患者表现出文字寻找暂停和句子重复受损,与lvPPA一致.
- 在患者的第二语言 (葡萄牙语) 中观察到最初的语言缺陷,并保留了对英语的理解.
- 神经成像和血生物标志物没有支持阿尔茨海默病的诊断.
结论:
- 这种病例表明了 lvPPA 的罕见表现,具有双语不对称性和负的阿尔茨海默病生物标志物.
- 在这种情况下,应考虑非阿尔茨海默氏症的病理,如初级与年龄相关的病 (PART) 或阿尔吉罗菲尔粒细胞疾病 (AGD).
- 液体生物标志物对于在lvPPA频谱内的拷贝的区分非常有价值.
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