Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

627
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
627
Depression: Overview01:18

Depression: Overview

777
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
777
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

437
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
437
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

451
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
451
Long-term Depression01:03

Long-term Depression

3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.1K
Long-term Depression01:05

Long-term Depression

33.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Epilepsy-Related Psychosis in Drug-Resistant Epilepsy With Nonconvulsive Status Epilepticus and Difficult Antipsychotic Titration: A Case Report.

Neuropsychopharmacology reports·2026
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026
Same author

Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.

European journal of drug metabolism and pharmacokinetics·2026
Same author

Electroconvulsive therapy in an older patient with recurrent major depressive disorder and a permanent pacemaker: A case report.

PCN reports : psychiatry and clinical neurosciences·2026
Same author

Associations of Functional Dyspepsia with Eating Behaviors and Stress-Coping Styles Among Japanese University Students.

Nutrients·2026
Same author

Theoretical Framework and Key Considerations for Time-to-Onset Analysis in Spontaneous Reporting Systems.

Drug safety·2026

相关实验视频

Updated: Jan 15, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K

确定低值抑郁症和主要抑郁障碍进展风险的生理和认知指标.

Ayaka Shimizu1, Satoshi Yokoyama2, Alan S R Fermin1

  • 1Department of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.

Neuropsychiatric disease and treatment
|January 14, 2026
PubMed
概括

低值抑郁症 (StD) 与类似于主要抑郁症 (MDD) 的生理和认知变化有关. 持续的性病症状可以预测MDD发作,突出潜在的早期检测标志物.

关键词:
认知功能 认知功能情感识别 情感识别 情感识别心率变化的心率变化.大型抑郁症主要是抑郁症.在值以下的抑郁症.语音分析是一种分析.

更多相关视频

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K

相关实验视频

Last Updated: Jan 15, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.2K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.2K

科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 心理学 心理学 心理学

背景情况:

  • 低值抑郁症 (StD) 呈现的症状低于主要抑郁症 (MDD) 诊断值.
  • 性病与功能障碍有关,并增加患MDD的风险.
  • 性病的客观生理和认知标记在很大程度上仍然没有被描述.

研究的目的:

  • 确定与下值抑郁症 (StD) 相关的客观生理和认知标志物.
  • 验证在患有性病的人群中出现重大抑郁症 (MDD) 的预测因素.

主要方法:

  • 168名大学生被评估,分为STD (n=87) 或控制 (n=81) 组,使用贝克抑郁 inventory-II (BDI-II).
  • 该STD组进一步划分为低 (BDI-II < 10) 和维持 (BDI-II ≥ 10) 的子组.
  • 评估包括语音分析,心率变化 (HRV),体温,情绪识别和神经认知任务,并对MDD发病进行随访.

主要成果:

  • 与对照组相比,STD组表现出增加的声音唤醒,更高的外周体温,以及降低的低频HRV.
  • 在性病组中观察到持续的注意力,执行功能和情绪识别 (快乐,惊的表情) 的障碍.
  • 维持抑郁症的小组表现出更严重的损伤和更高的MDD发作的发病率 (7例),而低抑郁症组没有MDD发作的选择性缺陷.

结论:

  • 性病与生理和认知异常有关,反映了MDD中的异常.
  • 在性病中持续的症状表明进展到MDD的风险更高.
  • 声音唤起,HRV,体温和情绪识别作为早期性病识别和风险分层的潜在标志物.