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血压多基因评分预测长期血压控制和耐治疗的高血压

So Mi Jemma Cho^1,2,3, Yunfeng Ruan^1,2, Hyeok-Hee Lee⁴

¹Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., Y.R., S.K., M.C.H., A.C.F., A.P., W.E.H., P.N.).

Hypertension (Dallas, Tex. : 1979)

|January 14, 2026

概括

基因预测血压 (BP) 使用多基因分数 (PGS) 可以识别长期低血压控制和耐治疗高血压的高风险个体. 这些遗传见解可以指导主动监测和密集治疗策略,以更好地预防心血管疾病.

科学领域:

心血管遗传学心血管遗传学
高血压研究高血压研究
精准医学是一门精准的医学.

背景情况:

低于最佳的血压 (BP) 控制是心血管疾病的重要危险因素.
基因预测的血压对长期血压控制的独立预测价值尚不清楚.

研究的目的:

调查BP多基因分数 (PGS) 与长期BP控制之间的关联.
为了检查BP PGS和治疗耐药高血压的发病率之间的关系.

主要方法:

利用了来自美国大众医院布里格姆生物银行 (Mass General Brigham Biobank) 的22456名高血压患者的数据.
纵向血压控制定义为5年内超过目标SBP (≥130 mmHg) 或DBP (≥80 mmHg) 的时间.
评估了使用多变量回归的关联,并在英国生物银行队列中验证了结果.

主要成果:

较高的血压PGS与超过目标的缩和腹缩血压持续时间较长有关.
患有高SBP和DBPP PGS的个体显著增加了患有耐治疗高血压的几率.
包括BP PGS改善了对抗治疗高血压的预测.

结论:

血压PGS可以预测长期的血压管理和耐治疗高血压风险.
使用BP PGS可以实现主动监测和有针对性的密集治疗,以改善BP控制.
遗传风险得分为个性化高血压管理策略提供了宝贵的见解.

关键词:

血压血压血压血压心血管疾病心血管疾病这种高血压,高血压.预后预后预后有关风险因素的风险因素.

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