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克鲁佩尔之类因子4,瘤微环境中细胞交叉通话的枢纽门

Min Tang¹, Binle Tian¹, Jingyi Zhou¹

¹Department of Medical Oncology, Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cancer medicine

|January 14, 2026

概括

克鲁佩尔样因子4 (KLF4) 在癌症中具有双重作用,作为瘤抑制剂或瘤基因. 它在瘤微环境 (TME) 中的复杂功能为向癌症治疗提供了潜在的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

克鲁佩尔样因子4 (KLF4) 是一种转录因子,在癌症中具有上下文依赖的作用.
KLF4可以作为瘤抑制剂或瘤基因起作用.
它在瘤微环境 (TME) 中的复杂作用对癌症进展至关重要.

研究的目的:

综合审查KLF4在TME中的多方面的作用.
评估KLF4作为瘤学中的潜在治疗点.
了解KLF4在TME中的细胞交叉声调的编排.

主要方法:

综合文献综述. 这是一个全面的文献综述.
分析KLF4表达模式和调节机制.
调查KLF4在各种TME组件 (癌细胞,免疫细胞,纤维细胞等) 的功能. ) 的情况.

主要成果:

KLF4表现出相反的作用:胃癌,肺癌和胰腺癌中的瘤抑制剂;乳腺癌,结肠直肠癌和前列腺癌中的瘤基因.
KLF4调节巨细胞极化,T细胞耗尽,NK细胞活动,以及骨髓系衍生抑制细胞的招募.
KLF4影响与癌症相关的纤维细胞激活和细胞外矩阵重塑,其表达由miRNAs,lncRNAs和表观遗传学调节.

结论:

KLF4作为TME内部细胞间通信的中央调节器.
了解KLF4的特定环境功能是开发精密瘤治疗的关键.
新兴的KLF4向剂在临床前和早期临床环境中表现有前途.

关键词:

在KLF4KLF4 癌症癌症癌症癌症癌症免疫细胞免疫细胞瘤微环境是一个微环境.

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