相关实验视频

Updated: Jan 15, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

新辅助免疫疗法在局部晚期口腔状细胞癌中的新兴作用:进展和挑战

Tong-Chao Zhao¹, Yi-Bin Dai, Zhi-Hang Zhou

¹Department of Oromaxillofacial Head and Neck Surgery, Center for Oromaxillofacial Head and Neck Disorders, Huashan Hospital, Fudan University, Shanghai, China.

International journal of surgery (London, England)

|January 14, 2026

概括

针对局部晚期口腔状细胞癌 (LAOSCC) 的新辅助疗法显示出有希望的结果,但需要进一步评估. 本综述探讨了化疗,化疗放射治疗,向治疗和免疫治疗,以提高LAOSCC患者的生存率.

科学领域:

在瘤学瘤学.
头部和部手术头部和部手术
免疫治疗是一种免疫疗法.

背景情况:

局部发达的口腔状细胞癌 (LAOSCC) 提出了重大管理挑战.
目前的标准治疗方法 (手术+辅助放射治疗/化学放射治疗) 导致5年生存率低于最佳 (~50%).
新辅助疗法在LAOSCC中的作用尚未完全确定,尽管有潜在的好处,如减少瘤负担.

研究的目的:

审查LAOSCC目前的新辅助治疗策略.
在LAOSCC中评估新辅助免疫疗法 (NAIT) 的疗效和安全性.
检查各种新辅助方法对临床实践的影响.

主要方法:

对LAOSCC的新辅助疗法现有证据的系统审查.
对化疗,化疗或放射治疗,向治疗和免疫治疗方案的分析.
对NAIT在头癌中的临床试验数据和文献的评估.

主要成果:

新辅助疗法旨在改善手术结果并减少LAOSCC中的转移.
免疫检查点抑制剂在复发性/转移性头癌中表现有前途,为LAOSCC带来了对NAIT的兴趣.
对于LAOSCC中NAIT的有效性和安全性数据仍然有限,需要进一步调查.

结论:

包括免疫疗法在内的新辅助策略正在探索,以增强LAOSCC治疗.
进一步系统地评估NAIT在LAOSCC中的有效性和安全性是至关重要的.
本综述综合了当前的知识,以指导LAOSCC新辅助疗法的未来临床实践和研究.

关键词:

生物标志物生物标志物免疫疗法免疫疗法主要病理反应的主要病理反应新辅助疗法是一种新辅助疗法.口腔状细胞癌的癌症.

更多相关视频

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...