Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

876
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
876

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks.

bioRxiv : the preprint server for biology·2026
Same author

Unraveling the complexity of the histone code: implications for gene regulation and disease.

Genome biology·2026
Same author

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia.

bioRxiv : the preprint server for biology·2026
Same author

Successful Resolution of Compartment Syndrome in a Pediatric Patient With B-cell Acute Lymphoblastic Leukemia.

Journal of pediatric hematology/oncology·2025
Same author

An Epigenetic Perspective of Gene Expression: The Regulatory Tools.

Critical reviews in eukaryotic gene expression·2025
Same author

Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity.

Cancer research·2025

相关实验视频

Updated: Jan 15, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

12.4K

皮卡尔姆:MLLT10 转位白血病

John M Cullen1, Antonia C Nakatsugawa1, Natalie Barton1

  • 1Department of Pediatrics, University of Vermont Larner College of Medicine, Burlington, USA.

FEBS letters
|January 14, 2026
PubMed
概括
此摘要是机器生成的。

PICALM::MLLT10染色体转位通过表观遗传变化驱动急性白血病. 用venetoclax针对这种白血病显示出有希望的结果,为患者提供了新的希望.

关键词:
在CALM-AF10中使用.皮卡尔姆:MLLT10 在这里.表观遗传控制是一种表观遗传控制.这种白血病是白血病.白血病转位转位是什么

更多相关视频

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.5K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

627

相关实验视频

Last Updated: Jan 15, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

12.4K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.5K
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

627

科学领域:

  • 血液学 血液学 血液学
  • 在瘤学瘤学.
  • 分子生物学分子生物学

背景情况:

  • 这种t(10;11)(p13;q14-21) 转位会产生CALM-AF10融合蛋白,这是急性髓性白血病和T-淋巴细胞白血病的关键驱动因素.
  • 这种白血病亚型的特点是表观遗传失调,包括导致基因组不稳定的全球低甲基化和推动扩散的焦点H3K79高甲基化.

研究的目的:

  • 提供关于PICALM::MLLT10急性白血病的病理生理学,临床表现,预后和治疗的最新概述.
  • 根据对疾病的更深入的生物学理解,突出潜在的治疗点.

主要方法:

  • 审查现有的文献和患者数据.
  • 推动PICALM::MLLT10白血病的分子机制的分析,包括表观遗传改变和蛋白质相互作用.
  • 评估最近的治疗干预措施,例如venetoclax治疗.

主要成果:

  • 皮卡尔姆:MLLT10白血病表现出明显的表观遗传特征,影响基因组稳定性和基因表达.
  • 转位与预后不佳和化学疗法耐药性有关.
  • 最近的研究表明,BCL2抑制剂venetoclax在治疗PICALM::MLLT10急性白血病方面具有有希望的疗效.

结论:

  • 皮卡尔姆:MLLT10急性白血病是一种由表观遗传驱动的恶性瘤,具有特定的临床和预后影响.
  • 新兴的治疗策略,包括像venetoclax这样的向疗法,为这种具有挑战性的白血病亚型提供了新的治疗途径.