一个双受体系统调解酸感应/降解以增强细菌毒性
Mengsi Zhang1,2, Mingming Yang1,3, Shuaiwu Wang1,2
1State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&F University, Yangling 712100, P. R. China.
Journal of agricultural and food chemistry
|January 14, 2026
概括
伪omonas syringae pv actinidiae (Psa) 使用一个双重系统来降解果.
科学领域:
- 植物病理学 植物病理学
- 微生物遗传学微生物遗传学
- 生物化学 生物化学
背景情况:
- 植物使用二次代谢物来防御病原体.
- 植物病原体发展出克服宿主免疫力的策略.
研究的目的:
- 为了研究 Pseudomonas syringae pv actinidiae (Psa) 如何对抗果的化学防御.
- 阐明Psa毒性和适应的分子机制.
主要方法:
- 研究了Psa_M228和果之间的相互作用.
- 分析了CasKR双组件系统和HcaR受体的作用.
- 研究了III型分泌系统 (T3SS) 和p-酸降解的调节.
主要成果:
- Psa_M228感知并降解宿主衍生的p-酸 (p-CA).
- 与Cask结合的p-CA通过降低T3SS的调节来抑制Psa的毒性.
- Psa利用HcaR和hca基因对p-CA进行代谢,逃避免疫力并恢复毒性.
结论:
- Psa_M228采用了一种复杂的反防御机制来对抗果的免疫力.
- 这种宿主-病原体相互作用凸显了植物疾病的进化军备竞赛.
- 了解这种机制可以为抗击基维果细菌性癌症 (KBC) 的策略提供信息.
更多相关视频
11:16A Hydroponic Co-cultivation System for Simultaneous and Systematic Analysis of Plant/Microbe Molecular Interactions and Signaling
Published on: July 22, 2017
14.6K
07:13Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
Published on: August 8, 2025
1.5K
相关概念视频
Gene Regulation in Microbial Communities: Quorum Sensing
517
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
517
Bacterial Signaling
40.1K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.1K
Global Regulatory Systems
598
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
598
Defenses Against Pathogens and Herbivores
29.5K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.5K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Transduction
1.2K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.2K
