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Updated: Jan 15, 2026

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
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一个Cas12i核酶的结构引导工程解锁了几乎没有PAM的基因组编辑

Qitong Chen1, Hanlin Gou1, Chao Xu1

  • 1Institute of Advanced Biotechnology, Institute of Homeostatic Medicine, and School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 14, 2026
PubMed
概括

研究人员设计了CRISPR-Cas12i核酶 (SF01变体),以克服原体空间器相邻动机 (PAM) 的限制. 这一突破将基因组编辑的可访问性扩展到超过25%的基因组,使新的治疗和研究应用成为可能.

关键词:
这就是Cas12i.没有PAM的PAM.基因组编辑 基因组编辑具有高特异性的高特异性

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