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高活性过氧化物纳米颗粒诱导化/氧化以促进癌症免疫代谢疗法

Qiu-Yi Duan¹, Liying Wang¹, Xi Cheng¹

¹Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, the Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200072, P. R. China.

|January 14, 2026

概括

过氧化物纳米颗粒 (SrPN) 通过逆转瘤酸化并增强免疫反应来对抗肝细胞癌 (HCC). 这种新的策略增强了抗癌免疫力,有效地破坏瘤.

科学领域:

生物医学工程生物医学工程
癌症研究癌症研究
免疫学免疫学免疫学

背景情况:

肝细胞癌 (HCC) 由于其免疫抑制性瘤微环境 (TME) 和酸性.
目前的治疗方法难以克服TME的劣质免疫性和代谢失调.
针对TME的代谢和免疫特征对于有效的HCC治疗至关重要.

研究的目的:

开发一种氧化-化策略,用于HCC的免疫代谢调节.
诱导免疫细胞死亡 (ICD) 并增强抗癌免疫反应.
调查乳酸在调节TME内的免疫反应中的作用.

主要方法:

通过轻度液相方法合成过氧化物纳米粒子 (SrPN).
利用SrPN诱导HCC细胞中的氧化应激和化.
在使用超声波导向皮肤注射的正型HCC模型中评估SrPN疗效.

主要成果:

SrPN有效地诱导HCC细胞中的ICD,促进树突细胞成熟和M1巨细胞极化.
化逆转了瘤诱导的酸性化,而H2O2介导的氧化应激增强了免疫反应.
乳酸放大了巨细胞的糖分水平,与SrPN协同促进M1极化和抗癌免疫力.
通过结合癌细胞杀死和TME免疫代谢调节,SrPN在体内显示出高瘤抑制效率.

结论:

使用 SrPN 开发的氧化-化策略显示,它有望增强 HCC 抗癌免疫力.
在TME内的代谢调节,利用乳酸等内代谢物,是提高治疗结果的关键.
在HCC治疗中,SrPN提供了一种生物相容且有效的免疫代谢调节方法.

关键词:

化的化药物输送是药物输送的过程.肝细胞癌是肝细胞癌.免疫代谢疗法是一种免疫代谢疗法.金属过氧化物纳米粒子金属过氧化物纳米粒子

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