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Updated: Jan 15, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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与癌症相关的SPOP突变体的系统性表征揭示了新的和可重编程的退化活动

Alana G Caldwell1, Harshil Parmar2, Xiaokang Jin2

  • 1Interdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, USA.

Chembiochem : a European journal of chemical biology
|January 14, 2026
PubMed
概括

前列腺癌中斑点类型POZ蛋白 (SPOP) 突变对蛋白质降解有不同的影响. 这些发现揭示了突变选择性E3链酶的潜在治疗应用.

关键词:
E3 结合酶的使用蛋白质蛋白质相互作用蛋白质组学 蛋白质组学经常性的突变突变.有针对性的蛋白质降解降解.

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