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预测和预后表现的虫毒症标准和虫毒症得分在PICU患者怀疑感染:一个多中心前性研究

Luca Marchetto¹, Marco Daverio¹, Rosanna Comoretto²

¹Pediatric Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.

Critical care medicine

|January 14, 2026

概括

与国际儿科败血症共识会议 (IPSCC) 标准相比,氏败血症标准 (PSC) 和氏败血症评分 (PSS) 在诊断和预测儿科败血症死亡率方面表现优异. 这些发现在儿童重症监护病房入院的第二天特别有所改善.

科学领域:

儿科重症监护医药儿科重症监护医药
传染病传染病传染病
临床诊断临床诊断临床诊断

背景情况:

儿童败血症的诊断和预后仍然具有挑战性.
像IPSCC这样的现有标准在准确性和及时性方面存在局限性.
需要新的评分系统来改善患者的治疗结果.

研究的目的:

评估毒性质标准 (PSC) 和毒性质评分 (PSS) 的预测和预后能力.
将PSC和PSS与国际儿科败血症共识会议 (IPSCC) 标准和其他器官功能障碍得分进行比较.
评估被怀疑感染入住儿科重症监护室 (PICU) 的儿童的表现.

主要方法:

一个多中心的前性队列研究,涉及意大利的八个PICU.
包括2022年2月至2024年4月怀疑感染的18岁以下患者.
使用IPSCC和PSC评估败血症,并计算各种器官功能障碍得分 (PSS,Phoenix-8,PELOD-2等). ) 的情况.

主要成果:

在第一天和第二天,PSC显示出比IPSCC标准更高的灵敏度和死亡率的积极预测值 (PPV).
儿科物流器官功能障碍-2 (PELOD-2) 评分显示出死亡率预测的精度回忆曲线 (AUPRC) 下的最高区域.
从PICU入院的第一天到第二天,所有预后表现都得到了改善.

结论:

在诊断和预测儿科败血症方面,PSC和PSS优于IPSCC的标准.
在PICU入院后的第二天,PSC和PSS的表现有所改善.
这项研究提供了PSC和PSS在欧洲儿科队列中的首次验证.

关键词:

国际儿科败血症共识会议国际会议共识会议城的败血症分数得分孩子们的孩子们的孩子们的孩子们.感染的感染感染.儿科重症监护病房儿童重症监护病房

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