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在COVID-19危急病患者的口服メラトニン:一个准实验的实用试验

Miguel Sánchez-García^1,2, Jesús A F Tresguerres^2,3, Manuel Álvarez-González¹

¹Department of Critical Care, Hospital Clínico San Carlos, Madrid, Spain.

Journal of medical virology

|January 14, 2026

概括

高剂量黑激素 (OBM) 在重症COVID-19患者中显著降低了90天死亡率. 这项研究发现OBM是安全有效的,改善了临床结果并减少了器官衰竭得分.

科学领域:

临界护理医学临界护理医学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

黑色素具有抗氧化,抗炎和潜在的抗病毒特性.
黑激素在重症COVID-19患者的治疗作用在疫情开始时还不清楚.
重症监护室 (ICU) 设置在治疗严重感染方面面临着独特的挑战.

研究的目的:

为了评估高剂量口服睡前黑激素 (OBM) 在重症COVID-19患者的疗效和安全性.
评估OBM对90天死亡率和器官功能的影响.
调查与OBM治疗相关的严重不良事件 (SAE) 的发生率.

主要方法:

一个准实验性的,务实的研究设计,交替控制和治疗期.
患者仅接受标准护理 (SoC) (控制) 或SoC加高剂量口服睡前黑激素 (50-200毫克) (治疗).
主要终点:90天死亡率. 二次结果:顺序性器官衰竭评估 (SOFA) 评分和SAE.

主要成果:

黑色素治疗与90天死亡率 (20.8%与36.1%) 的显著降低有关.
接受OBM治疗的患者在第4天和随后的访问中显示出较低的SOFA得分.
在OBM组中,SAE的发生频率较低 (41.6%对60.2%),这表明安全性较好.

结论:

高剂量口服黑激素是安全的,并且与重症COVID-19患者的改善临床结果有关.
黑素在降低死亡率和改善器官功能方面显示出潜在的益处.
对黑的抗病毒作用进行进一步的研究是有必要的,以应对未来的流行病.

关键词:

根据COVID-19的情况,在ICU中,医生会对患者进行治疗.通过口服服用的黑激素.在SARS-CoV-2中.急性呼吸困扰综合征是什么抗病毒效应抗病毒效应死亡率死亡率

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