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在为淋巴瘤接受治疗的FLNC突变患者接种COVID疫苗后的复发性心肌炎
Supreet Singh1, Lucy C Campbell1, Ike S Okwuosa1
1Division of Cardiovascular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
JACC. Case reports
|January 14, 2026
概括
通常导致心肌病的菲拉C (FLNC) 基因变异也可以表现为复发性心肌炎. 基因检测对于患有多发性心肌炎的患者至关重要,特别是患有淋巴瘤和COVID-19疫苗接种史的患者.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 纤维素C (FLNC) 变体主要与结构性心肌病相关.
- 肌心炎是FLNC变异的一个不常见的表现.
研究的目的:
- 在患有病原性FLNC变异的患者中报告复发性心肌炎病例.
- 强调基因检测在不明原因或复发性心肌炎中的作用.
主要方法:
- 一个60岁的男性患有B细胞淋巴瘤的病例报告.
- 在接种COVID-19疫苗和开始癌症治疗后诊断急性心肌炎.
- 门诊基因检测揭示了一种致病性FLNC变种.
主要成果:
- 患者经历了重复的急性心肌炎.
- 心脏骤停发生,需要多学科护理.
- 一种致病性FLNC变异被确定为潜在的潜在原因.
结论:
- 复发性心肌炎可能发生在FLNC突变的患者中,可能是由疫苗等外源因素引发的,以及在淋巴瘤和免疫治疗的背景下.
- 肌心炎可能是某些遗传性心肌病的初始临床表现.
- 对于患有复发性心肌炎发作的人来说,推进行基因检测.
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