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更年期状态与乳腺癌患者的多西素诱导的血管功能障碍相关

Piotr Szczepaniak¹, Tomasz P Mikolajczyk¹, Ewelina Jozefczuk¹

¹Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Cracow, Poland.

Journal of the American College of Cardiology

|January 14, 2026

概括

绝经前妇女受到化学疗法诱导的血管功能障碍的保护,与绝经后妇女不同. 雌激素可能保护绝经前妇女免受化疗.

科学领域:

心血管研究的心血管研究.
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

乳腺癌化疗显著增加心血管风险,特别是在绝经后的女性.
将更年期状态与化疗诱导的心血管风险联系在一起的机制尚不清楚.
研究了雌激素对化疗血管效应的保护作用.

研究的目的:

阐明化疗诱导的血管功能障碍的机制.
强调更年期状态对这些血管效应的影响.
专注于多塞塔克塞尔对血管的影响.

主要方法:

在绝经前和绝经后妇女的乳腺组织动脉中评估了血管功能,氧化应激和分子通路 (有/没有化疗).
在接受多塞塔塞尔或安慰剂治疗的卵巢切除和对照小鼠的机制研究.
评估了氧化的生物可用性,氧化应激标志物和特定的分子标.

主要成果:

化疗诱导了绝经后妇女的内皮功能障碍和降低了氧化的生物可用性,但不是绝经前妇女.
绝经前妇女对化疗诱导的氧化应激有抗性,NOX4表达率较低.
分子分析显示,在经过化疗后的绝经前妇女中,eNOS抑制和rho-kinase活性较少. 多塞塔克塞尔仅在卵巢切除的小鼠中引起功能障碍.

结论:

化疗诱导的血管功能障碍在绝经前妇女中不存在.
雌激素可能会对化疗的氧化应激和内皮氧化合成酶抑制提供保护.
更年期状态是化疗心血管副作用的关键因素.

关键词:

乳腺癌乳腺癌乳腺癌化疗化疗是一种化学疗法.多塞塔克塞尔 (Docetaxel) 是一种药物.内皮质功能障碍在内皮质功能障碍更年期绝经绝经

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