芬兰的肠:母亲的危险因素,患病率,相关异常和生存率

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Updated: Jan 15, 2026

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Esko Tahkola¹, Arimatias Raitio², Ilkka Helenius³

¹Department of Pediatric Surgery, Kuopio University Hospital, University of Eastern Finland and University of Helsinki, Helsinki, Finland.

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|January 14, 2026

概括

尽管经常出现相关异常,但先天性肠的死亡率很低. 孕产妇使用胰岛素和酸衍生品与增加核缩风险有关.

科学领域:

儿科手术儿科手术
医学遗传学医学遗传学
公共卫生公共卫生

背景情况:

先天性肠 (CIA) 涵盖结节 (JIA) 和结肠 (CA).
了解患病率,相关异常和生存率对于临床管理至关重要.
识别孕产妇的危险因素可以为预防策略提供信息.

研究的目的:

确定芬兰中情局的流行率和相关异常情况.
评估JIA和CA的生存率.
调查JIA的孕产妇风险因素.

主要方法:

来自芬兰先天性缺陷登记处的CIA案件 (1987-2019) 的回顾性分析.
包括来自国家卫生登记册的临床数据.
在JIA (2004-2017年) 中对孕产妇风险因素的病例控制研究,将101例与5个匹配的对照进行比较.

主要成果:

确定了175例JIA和48例CA病例;大约50%是孤立的异常.
常见的相关缺陷包括胃肠道 (26% JIA,35% CA),心脏 (13% JIA) 和泌尿道 (19% CA).
关节炎的生存率为88%和CA的94%,只有两个死亡直接归因于肠道缩. 母亲使用胰岛素 (aOR 8.4) 和酸衍生物 (aOR 4.6) 增加了JIA风险.

结论:

肠有较低的死亡率,即使有频繁的同时出现的异常.
孕产妇使用胰岛素和酸衍生物可能是发生状的重要危险因素.
对这些母亲暴露的进一步研究是有必要的.

关键词:

结肠缩症结肠缩症绝缘状腺缩症绝缘状腺缩症孕产妇的风险因素

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