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Updated: Jan 15, 2026

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大脑功能异常:在早期强迫症中,胰岛素信号通路基因多态和临床认知之间的桥梁

Hui Ding¹, Xu Shi², Minyao Xie³

¹Department of Psychiatry, The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou, 221004, China.

European child & adolescent psychiatry

|January 14, 2026

概括

一种特定的多态基因RACGAP1 rs297941与早期出现的强迫症 (EO-OCD) 有关. 这种遗传变异影响大脑功能,影响诸如信息处理速度之类的认知过程.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
精神病学是一个精神病学.

背景情况:

强迫症是一种神经发育障碍,与中央胰岛素信号通路有关.
早发性强迫症 (EO-OCD) 在理解其潜在机制方面提出了独特的挑战.

研究的目的:

研究中央胰岛素信号通路基因多态性和EO-OCD中大脑功能和临床特征之间的关系.
探索这些遗传变异如何影响认知功能和症状表现.

主要方法:

在EO-OCD患者和健康对照 (HCs) 中,候选单核酸多态 (SNPs) 的基因定型.
功能磁共振成像 (fMRI) 来评估大脑活动 (ALFF) 和功能连接 (FC).
使用MATRICS共识认知电池 (MCCB) 和调解分析进行认知评估.

主要成果:

RACGAP1 rs297941的多态性被确定为EO-OCD中胰岛素信号通路的关键因素.
在右前,右上边缘和后中心区域观察到低频波动 (ALFF) 幅度的异常.
在具有A基因基因的个体中,在几个大脑区域之间发现了增强的功能连接 (FC),包括右上边缘和补充运动区域,以及小脑和下顶区域.

结论:

rs297941的多态性与EO-OCD有显著的关联.
异常FC和ALFF调解了EO-OCD患者rs297941和信息处理速度之间的关系.

关键词:

脑部成像脑部成像早期出现的强迫症强迫症疾病.胰岛素信号传递途径早期出现的强迫症的神经生物学在RACGAP1基因中.

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