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泌尿中的植物性雌激素代谢产物与降低超尿血症风险有关

Xia Wang¹, Ye Zhang², Sutao Zhou¹

¹Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.

Clinical rheumatology

|January 14, 2026

概括

尿液中的植物性雌激素代谢物,包括equol和enterolactone,与较低的超尿血症 (HUA) 风险有关. 这项大型研究表明,植物雌激素可能会对HUA产生保护性益处.

科学领域:

环境健康环境健康
营养科学营养科学
代谢性疾病研究研究

背景情况:

超尿血症 (HUA) 是一种与各种健康问题相关的代谢状况.
植物雌激素是植物衍生化合物,具有潜在的健康益处.
了解植物雌激素暴露和HUA之间的关系对于公共卫生至关重要.

研究的目的:

调查尿液中单个植物性雌激素代谢产物与HUA之间的关联.
评估多种植物性雌激素代谢产物对HUA风险的综合作用.
确定影响HUA的关键植物雌激素代谢物.

主要方法:

从国家健康和营养检查调查 (NHANES) 中对9253名参与者的横截面分析.
测量尿中的植物性雌激素代谢产物:大idzein,o-desmethylangolensin (O-DMA),equol,genistein,enterodiol和enterolactone. 在尿中测量植物性雌激素代谢产物:大idzein,o-desmethylangolensin (O-DMA),equol,genistein,enterodiol和enterolactone. 在尿中测量尿中的植物性雌激素代谢产物:大idzein,o-desmethylangolensin (O-DMA),equol,genistein,enterodiol和enterolactone. 在尿中测量尿中的植物性雌激素代谢产物:大idzein,o-desmethylangolensin (O-DMA),等.
应用加权后勤回归,平滑曲线拟合,WQS回归,量子式g计算和BKMR模型来评估代谢物-HUA关系.

主要成果:

大约18.33%的参与者有HUA.
尿路戴泽因,O-DMA,equol和肠乳与降低HUA风险有关.
混合的植物雌激素代谢产物与HUA呈现负相关性,其主要贡献者是equol和enterolactone.

结论:

混合的尿路植物雌激素代谢产物与HUA风险相反相关.
乙醇和肠乳是植物雌激素对HUA的保护作用的关键贡献者.
研究结果支持促进植物雌激素摄入以预防HUA的公共卫生策略,尽管无法确定因果关系.

关键词:

贝叶斯核机器回归贝叶斯核机器回归超性血症 (hyperuricemia) 是一种疾病,尼汉斯 (NHANES) 是一个名人.量子的g-计算方式.尿路中的植物性雌激素.权重的量化数量总和.

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