改变的p53基因表达在冠状动脉疾病患者与失脂血症:对Atherogenesis的影响
Reshma Gopan M1,2, Deepika Chandrasekaran3, Dinesh Roy D4
1Department of Physiology, Meenakshi Academy of Higher Education and Research, Chennai, India. reshmagpn@gmail.com.
概括
在年轻的印度冠状动脉疾病 (CAD) 患者中,p53基因表达升高,与脂质异常和压力标志物相关. 这表明p53是p53.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 冠状动脉疾病 (CAD) 在年轻的印度人中正在上升,需要早期的血管应激生物标志物.
- 已知瘤抑制基因p53在血管亡和炎症中的作用,但其与CAD中代谢和化应激的联系尚不清楚.
研究的目的:
- 研究p53作为CAD的综合生物标志物.
- 在CAD患者中分析p53基因表达,脂质样本以及炎症 (IL-6) 和化 (3-化素) 标志物之间的关系.
主要方法:
- 一项涉及90名CAD患者和90名健康对照 (18-50岁) 的病例控制研究.
- 通过酶学评估脂质特征,通过RT-PCR评估p53基因表达,并使用ELISA评估IL-6/3-尼托氨酸水平.
- 统计分析包括t测试,曼-惠特尼U,奇平方和皮尔森相关性.
主要成果:
- 与对照组相比,CAD患者的总胆固醇,甘油三,LDL-C,IL-6和3-NT都较高,HDL-C较低 (p < 0.01).
- 在CAD患者中,p53基因表达被调高了1.6倍.
- p53与3-尼托铁素 (r=0.709,p<0.001) 和IL-6 (r=0.513,p<0.01) 有正相关性.
结论:
- 这项研究提供了第一个印度证据,将p53基因表达与年轻CAD患者的脂质,炎症和化标志物联系起来.
- 这些发现为早期动脉动脉生成和p53作为生物标志物的潜力提供了新的分子洞察力.
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