电子干预患者管理的奔二二胺缩:一个随机临床试验
Keith Humphreys1,2, Hildi Hagedorn3,4, Xiaotong Han5,6,7
1Center for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California.
JAMA network open
|January 14, 2026
概括
电子自我管理干预 (EMPOWER-ED) 在长期使用者中显著增加了二类药物戒断. 这种低成本的数字工具为减少依赖和相关风险提供了可扩展的解决方案.
科学领域:
- 临床医学 临床医学
- 数字健康数字健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期使用二类药物影响着超过3000万美国人,带来诸如摔倒,认知衰退和依赖等风险.
- 一项先前的试验证明了EMPOWER自我管理干预措施在减少二胺依赖方面的有效性.
研究的目的:
- 通过将干预程序转换为电子格式 (EMPOWER-ED) 来复制 EMPOWER 试验的结果.
- 评估EMPOWER-ED干预措施在减少长期使用二胺药物的有效性.
主要方法:
- 一项随机临床试验,涉及161名初级保健患者长期使用二.
- 参与者被随机分配到电子 EMPOWER-ED 干预或治疗中,像往常一样.
- 结果包括完全停止使用二,并在6个月的随访期至少减少25%的剂量,通过药房数据进行评估.
主要成果:
- EMPOWER-ED组显示完全停止使用二的可能性明显更高 (OR,5.31).
- 两组之间在实现至少25%的剂量减少方面没有发现显著差异.
- 与焦虑,睡眠和生活质量相关的二次结果没有显著差异.
结论:
- 电子交付的EMPOWER-ED干预措施有效地促进长期使用者停止使用二.
- 这种低成本,自我管理的数字工具为管理二类药物依赖提供了一个有希望的,可扩展的方法.
- 由于干预的公共领域地位和已证明的有效性,建议卫生保健系统广泛采用.
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