精神疾病作为急性冠状动脉综合征的危险因素:系统性审查和元分析
Arnav Gupta1, Tushar Tejpal2, Chanhee Seo1
1Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
JAMA psychiatry
|January 14, 2026
概括
精神障碍如抑郁,焦虑,PTSD和睡眠障碍显著增加了急性冠状动脉综合征 (ACS) 的风险. 早期发现和治疗这些疾病对于心血管健康至关重要.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 精神疾病越来越被认为是导致心血管疾病的潜在因素.
- 传统的心血管风险因素可能会调解精神健康状况和急性冠状动脉综合征 (ACS) 之间的联系.
研究的目的:
- 系统地审查和元分析各种精神障碍与发展ACS的风险之间的联系.
- 量化诊断出精神健康状况的个体与没有精神健康状况的个体中ACS的风险.
主要方法:
- 在MEDLINE,Embase和PubMed数据库中进行了全面的搜索.
- 包括的研究是观察性或随机的,评估精神障碍和ACS事件之间的关联.
- 用随机效应元分析提取和合成数据,并遵守PRISMA 2020指南.
主要成果:
- 该元分析包括了25项研究,涉及超过2200万参与者.
- 抑郁障碍 (HR 1.40),焦虑障碍 (HR 1.63),睡眠障碍 (HR 1.60) 和创伤后应激障碍 (PTSD) (HR 2.73) 与增加的ACS风险显著相关.
- 在本次分析中,双极性和精神病障碍与ACS没有显著的关联.
结论:
- 抑郁障碍,焦虑障碍,PTSD和睡眠障碍与ACS的更高风险有关.
- 创伤后应激障碍和睡眠障碍是显著的风险因素,突出显示了睡眠质量对心血管结果的重要性.
- 需要进一步的研究来阐明心理健康和ACS之间的复杂关系.
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