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Updated: Jan 17, 2026

Overexpressing and Purifying a Toxic Nuclease from Escherichia coli
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金属离子控制着冠状病毒内核酶活性

Xionglue Wang1, Jing Li2, Zhichao Liu1

  • 1Key Laboratory of Molecular Biophysics, the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan430074, China.

Nucleic acids research
|January 14, 2026
PubMed
概括

金属离子调节冠状病毒nsp15活动. (Co2+) 和 (Ni2+) 激活了该酶,而 (Zn2+) 抑制了它,揭示了对病毒复制和宿主免疫逃避至关重要的新型调节机制.

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