身体脂肪比率和胆结石疾病风险:一项横截面研究确定了 29.1 的非线性风险值
Haiyuan Zhao1, Yongxin Fang1, Nianzhao Yang1
1Department of General Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, China.
Science progress
|January 14, 2026
概括
身体脂肪比率 (BFR) 显著增加了超过29.1%的值的胆结石病 (GSD) 风险. 监测BFR可能有助于早期发现GSD,并根据性别和种族差异进行有针对性的干预.
科学领域:
- 代谢健康 代谢健康
- 流行病学 流行病学
- 胃肠病学 胃肠病学
背景情况:
- 像BMI这样的传统肥胖指标不能完全捕捉脂肪分布对胆结石疾病 (GSD) 的影响.
- 了解身体脂肪比率 (BFR) 和GSD风险之间的关系对于公共健康至关重要.
- 确定BFR的关键值可以改善GSD的风险分层.
研究的目的:
- 调查身体脂肪比率 (BFR) 与胆结石疾病 (GSD) 风险之间的非线性关联.
- 确定与增加GSD风险相关的BFR的关键值.
- 探索人口学子组之间这种关联的潜在差异.
主要方法:
- 来自2017-2018年国家健康和营养检查调查 (NHANES) 的1952名成年人的横截面分析.
- 身体脂肪比率 (BFR) 通过双能X射线吸收计测量;GSD通过问卷定义.
- 用于分析BFR-GSD关联的加权后勤回归,限制立方线 (RCS) 和值效应模型.
主要成果:
- 在BFR和GSD风险之间发现了显著的J形非线性关联 (P < 0.001).
- 确定BFR的临界拐点为29.1%,超出这一点后,GSD风险显著增加.
- 在调整后,BFR每增加1%至29.1%以上都与GSD风险增加7%有关 (OR=1.07).
- 与最低四分位数相比,BFR最高四分位数 (≥39.2%) 的个体患GSD的风险高出2.66倍.
结论:
- 身体脂肪比率 (BFR) 为29.1%或更高,代表了明显增加胆结石病 (GSD) 风险的关键值.
- 常规BFR监测可以成为高风险人群中GSD的有价值的查工具.
- 与代谢相关的GSD的干预策略应考虑性别和种族差异,以提高有效性.
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