糖尿病和老年人肌肉功能低下之间的双向关系:来自两个基于人口的研究的数据
Caterina Trevisan1,2,3, Francesca Remelli1,3, Stefania Bandinelli4
1Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
概括
糖尿病加快了老年人肌肉力量的下降,肌肉力量的下降增加了糖尿病的风险,表明循环关系. 需要进一步的研究,看看提高肌肉力量是否可以降低糖尿病发病率.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 骨肌肉功能障碍是老年人,特别是糖尿病患者残疾的主要原因.
- 糖尿病是老年人常见的并发症,严重影响移动性和生活质量.
研究的目的:
- 为了研究糖尿病与老年人肌肉强度下降的速度之间的联系.
- 为了确定较低的基线肌肉强度是否预测老年人群中糖尿病发病率较高.
主要方法:
- 来自意大利两项以人口为基础的研究 (Invecchiare in Chianti 和 Progetto Veneto Anziani) 数据的前性分析.
- 在基线和两次随访 (中位数为4.4年和6.3年) 中使用多个来源评估糖尿病状况.
- 肌肉功能通过手握强度来衡量.
主要成果:
- 与没有糖尿病的人相比,患有糖尿病的个体肌肉力量下降的幅度更大,即使调整了混因素.
- 糖尿病和肌肉力量下降之间的关联在使用口服抗糖尿病药物的人群中更为明显.
- 相对于体重,较高的手握强度与在中位数5年随访期间显著降低患病糖尿病的可能性有关.
结论:
- 在老年人中,糖尿病和骨肌肉力量之间存在显著的,独立的,循环的关系.
- 肌肉功能障碍可能是老年人糖尿病的长期并发症.
- 旨在增加肌肉力量以减轻糖尿病风险的干预措施的潜力需要进一步调查.
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