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Updated: Jan 17, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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普雷福丁5是一种与微管相关的蛋白质,可以抑制tau聚合和神经毒性

Anjali Bisht1, Srikanth Pippadpally1, Snehasis Majumder2

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, India.

eLife
|January 14, 2026
PubMed
概括

在神经退行性疾病中,Prefoldin 5 (Pfdn5) 伴侣蛋白调节Tau的毒性. 失去Pfdn5会使Tau病理变得更糟,而过度表达会改善模型中的神经退行和记忆缺陷.

关键词:
D. melanogaster. D. 黑色巨 (Melanogaster) 是一种有毒的植物.陪伴者就是一个陪伴者.学习和记忆的学习和记忆.微管是微管的组成部分.神经退行症的神经退行症神经科学 神经科学在 prefoldin 中进行预折叠.病症是一种病症.

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