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Updated: Jan 17, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

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一个转化酶衍生的基因,对人类大脑发育所需的基因

Luz Jubierre Zapater1,2, Sara A Lewis3, Rodrigo Lopez Gutierrez4

  • 1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

Science advances
|January 14, 2026
PubMed
概括

PiggyBac可移植元素衍生5 (PGBD5) 对于正常的大脑发育至关重要. 它在人类和小鼠中的缺乏导致智力障碍,运动障碍和,原因是DNA重塑和基因组重组.

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DNA-only Transposons02:57

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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