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含果糖的甜饮料在儿科MASLD中诱导昼间氧化还原失调

Helaina E Huneault¹, Scott E Gillespie², Zachery R Jarrell³

¹Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA; Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA.

|January 14, 2026

概括

患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的儿童表现出改变的氧化还原平衡. 果糖摄入量加剧了这种不平衡,增加了氧化应激,降低了谷氨水平,建议减少果糖作为治疗策略.

科学领域:

儿科内分泌学儿科内分泌学
营养生物化学营养生物化学
代谢性疾病研究研究

背景情况:

血氧化还原对 (谷氨酸/谷氨酸二硫化物和氨酸/氨酸) 在成年人中呈现白天变化,并且在与肥胖相关的疾病 (如MASLD) 中更加氧化.
关于儿童的氧化还原状态的研究有限,没有关于糖的影响的数据,尽管消费率很高.

研究的目的:

为了描述儿童的日间氧化还原对变化.
评估MASLD对氧化还原状态的影响.
评估果糖与葡萄糖饮料对儿科氧化还原平衡的差异性影响.

主要方法:

一项为期2天的随机,受控,交叉养研究,涉及26名儿童 (12名MASLD,14名对照;年龄在10-18岁).
摄入与果糖或葡萄糖饮料一起的同热量饮食,然后在24小时内每隔2小时抽取血液.
对囊/囊和谷/谷二硫化物水平的分析,用Nernst方程计算的氧化还原潜.

主要成果:

在果糖和葡萄糖饮料消费后,在血氧化还原潜力 (E_h(GSH/GSSG) 和E_h(Cys/CySS)) 中观察到显著的白天变化.
患有MASLD的儿童在果糖饮料中表现出显著更多的氧化E (GSH/GSSG),与葡萄糖不同.
果糖摄入导致E_h(GSH/GSSG) 氧化增加,并在患有MASLD的儿童中一夜之间降低了GSH水平.

结论:

血氧化还原状态在儿童中表现出白天变化,在患有MASLD的儿童中氧化程度更高.
果糖消费加剧了小儿MASLD中的氧化应激,通过氧化GSH/GSSG对并降低GSH水平.
这些发现强调了果糖是儿科MASLD相关的氧化还原失衡的关键因素,支持果糖减少和谷氨恢复作为潜在的治疗点.

关键词:

饮食中的糖类是饮食中的糖.葡萄糖氨酸 (Glutathione) 是一种肝脏肥胖症肝脏肥胖症氧化应激是一种氧化应激.

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Glucose Transporters

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: