文章标题:烯暴露与乳腺癌风险之间的关联:综合性流行病学,网络毒理学,多组学和实验分析
Liu Ji1, Guiting Yang1, Maoyao Ling1
1Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
Ecotoxicology and environmental safety
|January 14, 2026
概括
暴露于常见的防腐剂 - - 类 (PBs) 与增加乳腺癌风险有关. 这些化学物质可能会破坏激素通路并促进癌细胞生长,这表明它们是乳腺癌的潜在环境贡献者.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 乳腺癌是全球女性的主要恶性瘤.
- 环境化学物质暴露越来越多地与乳腺癌的发展有关.
- 烯 (PBs) 是广泛使用的具有内分泌干扰特性的防腐剂,但它们在乳腺癌发生中的作用尚不清楚.
研究的目的:
- 调查素暴露与乳腺癌风险之间的关联.
- 探索这种关联背后的潜在分子机制.
- 为了确定关键的分子标和途径,涉及到帕拉本诱导的乳腺癌发生.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2005-2016) 的流行病学分析.
- 网络毒理学,机器学习 (SHAP),转录基因分析,分子对接和体外测试.
- 利用了尿液中的帕拉本度,基因表达数据和基于细胞的实验.
主要成果:
- 尿液中乙基 (EPB),甲基 (MPB) 和基 (PPB) 的较高度与乳腺癌患病率有显著的关联.
- 雌激素受体1 (ESR1),增强体2多抑制复合体2亚单元 (EZH2) 的增强剂和PDGFRA被确定为关键分子标,其中EZH2是最有影响力的.
- 实验室研究表明,PBs可上调ESR1和EZH2,诱导DNA损伤,增强乳腺癌细胞的增殖和迁移.
结论:
- 类化合物可能通过影响激素通路和瘤微观环境来促进乳腺癌的进展.
- 识别的分子标 (ESR1,EZH2) 在调解PBs的影响方面至关重要.
- 这些发现突出了PBs作为乳腺癌的潜在环境风险因素.
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