怀孕期间的母体血清多化二乙烯度和12岁的青少年骨矿物质密度
Katherine M Marquess1, Jordan R Kuiper2, Bruce P Lanphear3
1Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
International journal of hygiene and environmental health
|January 14, 2026
概括
在子宫内接触多二乙烯 (PBDE) 可能会对青少年的骨矿物质密度 (BMD) 产生负面影响. 妊娠期PBDE水平与较低的BMD Z-分数有关,特别是在男性中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 儿童骨健康 儿童骨健康
背景情况:
- 聚乙乙烯 (PBDE) 是阻燃剂,具有已知的发育毒性.
- 产前PBDE暴露对青少年骨健康的影响在很大程度上是未知的.
- 机理学研究表明PBDE是骨质毒剂.
研究的目的:
- 研究怀孕期间母亲血清PBDE度与青少年骨矿物质密度 (BMD) 之间的关联.
- 探索子宫内PBDE暴露对骨健康的潜在性别特异性影响.
- 检查PBDE和有机酸 (OPE) 混合物对青少年BMD的联合作用.
主要方法:
- 在母体血清中量化了5个PBDE,在母体尿液中量化了4个OPE代谢物,来自184对母婴.
- 在12岁时使用双能X射线吸收计测量青少年的BMDZ-scores.
- 采用线性回归和基于量子的g计算来分析关联和混合效应,评估基于性别的效应修改.
主要成果:
- 在青少年中,母亲的BDE-153度与部下部BMDZ-score有关.
- 某些PBDE (BDE-28, -47, -100) 和BMD之间的关联因青少年的性别而改变,在男性中观察到BDE-28的更强的负面影响.
- PBDE和OPE混合物显示出与骨质疏松症的弱点,特定于位点的关联,置信区间超过了零点.
结论:
- 在子宫内暴露于PBDE可能会对青少年的骨健康产生不利影响.
- 孕期PBDE暴露与青春期骨矿物质密度降低有关,有潜在的性别差异.
- 需要进一步的研究,以了解产前接触阻燃剂和相关环境化学物质对骨的长期后果.
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