颗粒物对血脑屏障的影响
Chang Guo1, Sanghamitra Mukhopadhyay2, Laura Zanetti Domingues3
1Toxicology Department, UK Health Security Agency (UKHSA), Harwell Campus, Oxfordshire, OX11 0RQ, UK; National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, UK.
The Science of the total environment
|January 14, 2026
概括
环境颗粒物 (PM) 可以影响大脑. 这项研究表明,PM与血脑屏障细胞直接相互作用,可能通过血膜穿越到大脑.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 细胞生物学 细胞生物学
背景情况:
- 吸入的环境颗粒物 (PM) 对神经元健康构成风险.
- 对于PM神经毒性的机制,包括血脑屏障 (BBB) 的穿越,尚未完全理解.
- 潜在的途径包括嗅觉神经运输或与BBB的直接相互作用.
研究的目的:
- 为了研究循环中的PM如何通过内皮细胞穿过BBB.
- 阐明血在PM与BBB相互作用中的作用.
- 用先进的显微镜和散射技术检查粒子膜相互作用.
主要方法:
- 使用一个体外BBB模型 (hCMEC/D3细胞).
- 暴露于伦敦环境PM (PM10,PM2.5) 和柴油废气颗粒 (DEP) 的电池.
- 采用聚焦离子束扫描电子显微镜 (FIB-SEM),共聚焦显微镜和准弹性中子散射 (QENS).
主要成果:
- FIB-SEM确定了电子密度高,基于碳的粒子与细胞模型相互作用.
- 纳米化PM分量与等离子体膜有显著的关联.
- QENS数据表明,暴露后的膜动态发生了实质性的变化.
结论:
- 与内皮质等离子膜的直接PM相互作用有助于粒子吸收.
- 这种相互作用代表了PM大脑暴露的关键途径.
- 这些发现突出了PM诱导的神经毒性的关键机制.
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