相关实验视频

Updated: Jun 19, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

怀孕期间的高环境温度和后代脑:加利福尼亚州的一项基于人口的病例控制研究

Haoran Zhuo¹, Joshua L Warren², Giselle Bellia¹

¹Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT; Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, CT.

Environmental research

|January 14, 2026

概括

在怀孕早期,产前暴露于高环境温度与儿童脑 (CP) 风险增加有关. 这一发现突显了环境因素对神经发育结果的影响.

科学领域:

环境流行病学环境流行病学
神经发育障碍神经发育障碍
儿科健康儿科健康

背景情况:

大脑 (CP) 是儿童神经运动残疾的主要原因.
环境因素越来越多地被认为对CP病因学的作用.
产前热暴露对CP风险的影响需要进一步调查.

研究的目的:

检查产前暴露于高环境温度和后代脑风险之间的关联.
量化与怀孕期间不同程度和持续时间的热暴露相关的CP风险.

主要方法:

在加利福尼亚州 (2005-2015) 进行了一项嵌套病例对照研究,包括5938例CP病例和1092313例对照.
孕期温度估计使用高分辨率数据在孕产妇住所.
使用分布式滞后模型和兄弟分析的物流回归被用于评估热暴露和CP风险.

主要成果:

在怀孕早期,CP风险增加与周周环境温度上升5°C (OR:1.02,95%CI:1.01-1.05) 和暴露于极端热量 (OR:1.04-1.05,95%CI:1.00-1.13) 相关.
随着时间的推移,累积的热暴露显示出与CP风险的较强关联 (ORs:1.08-1.18).
兄弟分析支持观察到的趋势,表明发现的稳定性.

结论:

怀孕早期暴露于环境温度升高与患脑的风险更高有关.
这些发现强调了在气候变化背景下监测神经发育障碍的必要性.
公共卫生策略可能需要考虑在怀孕期间减轻热量暴露.

关键词:

脑性麻脑性麻是一种疾病.环境温度环境温度环境温度在产前暴露,产前暴露.易受影响的窗户.

更多相关视频

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

相关概念视频

Regression Toward the Mean

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...

Environmental Influences on Intelligence

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children from...