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在REGARDS研究中饮用水,尿液生物标志物和认知障碍

Meghan Angley¹, Yijia Zhang¹, Anne E Nigra²

¹Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.

Environmental research

|January 14, 2026

概括

尿液中的无机 (iAs),特别是MMA和iAs,与认知障碍有关. 这项研究强调了考虑和认知的各种暴露措施的重要性.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

无机 (iA) 暴露是成年人认知障碍的已知危险因素.
饮用水中的,个体毒动力学和认知能力下降之间的关联存在有限的研究.
了解这些联系对于公共卫生干预至关重要.

研究的目的:

调查个人水平的尿生物标志物,饮用水中的县级和认知障碍之间的关联.
检查毒动因学的差异及其对不同群体认知的影响.
为减轻与有关的认知风险制定策略.

主要方法:

使用"脑卒中地理和种族差异的原因" (REGARDS) 队列,将参与者与县级数据联系起来.
无机 (iAs),单甲基酸 (MMA) 和二甲基酸 (DMA) 的尿度被测量为一个子集.
用六项选器 (SIS) 和增强认知电池 (ECB) 评估认知障碍,并应用多变量逻辑回归.

主要成果:

尿液中MMA和IA度较高显著与认知障碍的几率增加有关.
公用水和私人井中的县级与认知障碍无关.
在不同的认知评估工具中,研究结果一致.

结论:

尿中的代谢物,特别是MMA和IA,是引起的认知障碍的潜在生物标志物.
这项研究强调了需要考虑个人毒性动力学以及环境暴露水平的必要性.
需要进一步的研究来阐明将暴露与认知衰退联系在一起的机制.

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