相关实验视频

Updated: Jan 17, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

顺序相同的捐赠者与不匹配的无血缘捐赠者在减少强度的条件干细胞移植中,GETH-TC研究

María Laura Fox¹, Ariadna Pérez Martínez², Albert Esquirol³

¹Department of Hematology, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain; Universidad Autònoma de Barcelona (UAB), Barcelona, Spain.

Transplantation and cellular therapy

|January 14, 2026

概括

使用移植后循环胺 (PTCy) 的哈普洛相同 (HAPLO) 和不匹配的无关献体 (MMUD) 干细胞移植提供了类似的生存结果. 没有PTCy的MMUD与更高的慢性移植与宿主疾病 (GVHD) 率有关,使得基于PTCy的方法更可取.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

选择最优的捐赠者用于全源干细胞移植 (HSCT) 是至关重要的,特别是当匹配的捐赠者是不可用的.
哈普洛相同 (HAPLO) 和不匹配的无血缘供体 (MMUD) HSCT 越来越多地被认为是替代品.
使用降低强度调节 (allo-RIC) 和各种移植对宿主疾病 (GVHD) 预防策略.

研究的目的:

为了比较HAPLO和MMUD HSCT之间的移植对宿主疾病和无复发生存率 (GRFS).
根据不同的GVHD预防策略来评估结果,特别是移植后环胺 (PTCy).
评估二次终点,包括生存率,死亡率,复发率和GVHD发病率.

主要方法:

从2012年1月到2022年3月在12个中心进行首次RIC HSCT的回顾性分析.
队列包括HAPLO (基于PTCy的GVHD预防) 和MMUD (基于PTCy或替代性预防).
对GRFS,总生存率 (OS),无病生存率 (DFS),非复发性死亡率 (NRM) 和GVHD率进行比较.

主要成果:

在HAPLO (47%),MMUD-PTCy (52%) 和MMUD-OTHERS (43%) 组中,两年的GRFS是可比的 (p=0.8).
在MMUD组中,复发是GRFS失败的主要原因,而NRM在HAPLO组中占主导地位.
PTCy预防与较低的中度/重度慢性GVHD发病率有关 (12.2%的HAPLO,11%的MMUD-PTCy与21.7%的MMUD-OTHERS).

结论:

使用PTCy的HAPLO和MMUD HSCT实现了可比的GRFS,OS,复发和NRM.
没有PTCy的MMUD与中度至重度慢性GVHD的发病率较高有关.
在没有完全匹配的捐赠者时,建议使用基于 PTCy 的 GVHD 预防.

关键词:

这里是RIC RIC.全源性造血细胞移植细胞移植一个单双相同的捐赠者.没有匹配的捐赠者.降低了毒性的毒性

更多相关视频

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...