Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Author Correction: Ventricular assist device unloading reverses microvascular senescence in single ventricle disease.

Nature cardiovascular research·2026
Same author

Trainable clustering framework for spatial transcriptomics.

Bioinformatics advances·2026
Same author

Ventricular assist device unloading reverses microvascular senescence in single ventricle disease.

Nature cardiovascular research·2026
Same author

Predicting protein-carbohydrate binding sites: a deep learning approach integrating protein language model embeddings and structural features.

Briefings in bioinformatics·2026
Same author

YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity.

Circulation research·2025
Same author

ResLysEmbed: a ResNet-based framework for succinylated lysine residue prediction using sequence and language model embeddings.

Bioinformatics advances·2025
Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026
Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026
Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026
Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026
Same journal

Spatially resolved profiling of steroid nuclear receptors reveals a role for the disordered N-terminal domains in genome targeting and AP-1 interaction.

Genome research·2026
Same journal

Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr.

Genome research·2026
查看所有相关文章

相关实验视频

Updated: May 13, 2026

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
13:13

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

11.0K

从单细胞转录组数据用scPSSS量化病理进展.

Samin Rahman Khan1,2, M Saifur Rahman3, M Sohel Rahman4

  • 1Institute of Information and Communication Technology, Bangladesh University of Engineering and Technology, Dhaka-1000, Bangladesh.

Genome research
|January 14, 2026
PubMed
概括
此摘要是机器生成的。

我们开发了单细胞病理转移评分 (scPSS) 来量化疾病细胞如何偏离健康细胞状态. 这种统计严格的方法准确地在单个细胞水平上测量病理进展.

更多相关视频

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

7.1K
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

19.0K

相关实验视频

Last Updated: May 13, 2026

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
13:13

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

11.0K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

7.1K
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

19.0K

科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 生物统计学 生物统计学

背景情况:

  • 单细胞数据分析正在快速发展,使得不同条件的比较成为可能.
  • 在从健康状态量化单细胞水平的病理变化方面存在关键差距.
  • 现有的方法缺乏以半监督的方式测量细胞水平的病态进展的能力.

研究的目的:

  • 引入单细胞病理转移评分 (scPSS),一种用于量化单细胞病理转移的新型统计方法.
  • 提供一个统计严格的测量一个查询单元偏离健康的参考群体多少.
  • 为了使病理进展的评估,而不需要标记的病情数据进行培训.

主要方法:

  • scPSS根据查询单元到其在主要组件空间中的k-th最近参考单元的距离计算病态转移得分.
  • 欧几里德距离计算在基因表达数据的顶部n个主要组件空间中.
  • 使用参考健康细胞的转移分数分布建立一个零模型,使P值赋值成为可能.

主要成果:

  • scPSS为单个细胞提供了病理偏差的统计严格和可解释的测量.
  • 该方法在基准测试中与适应的最先进的监督模型相比,显示出更高的准确性和效率.
  • 综合的细胞水平scPSS得分可以有效地预测个体水平的健康状况.

结论:

  • scPSS提供了一种强大的,半监督的方法来量化细胞水平的病理变化,解决单细胞分析中的一个关键差距.
  • 该方法的统计学严谨性和效率使其成为疾病研究的宝贵工具.
  • scPSS在疾病诊断和监测方面具有潜在的应用,通过使个人健康水平的预测成为可能.