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对于应力颗粒和P体组件,需要tRNA合成酶活性

Max Baymiller1,2,3, Noah S Helton1,2, Benjamin Dodd1,2

  • 1Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Genes & development
|January 14, 2026
PubMed
概括

阻断tRNA氨基化会导致持续的核糖体停滞,抑制RNP颗粒组装尽管集成应激反应 (ISR) 激活. 普罗米辛治疗释放了这些摊位,恢复了颗粒的形成,并突出了翻译质量控制.

关键词:
在P体中,P体是P体.有一种叫做 halofuginone 的成分.综合应激反应综合应激反应核糖体碰撞 核糖体碰撞与核糖体相关的质量控制压力颗粒是压力颗粒.这是一种tRNA合成酶.翻译 延长 延长 翻译

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